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Abstract

HUMAN GENETIC VARIATION SUSCEPTIBILITY ASSOCIATED WITH HBV: ANALYSIS OF GENETIC MARKERS SUSCEPTIBILITY TO HEPATITIS B AMONG PATIENTS IN BABYLON PROVINCE

Ali Hussein Al-Marzoqi*, Nisreen Kaddim Radi, Ammal Raqib Shamran

ABSTRACT

Background: Hepatitis is a serious public health problem distressing many of people worldwide. Inadequate data is available on this issue in Iraq. This study was carry out with the aim of determining the genetic SNPs in human and risk factors of hepatitis C virus (HCV) among the general population and among blood donors. Methods: Blood samples from volunteers; have been screened with ELISA tests for detecting the hepatitis- surface antigen and using PCR for the same purpose. In addition we used some genes to study the prevalence of hepatitis severity with human genes polymorphism like IFNGR, IFN-γ and IL- 28B gene. Results: The characteristics of the 248 patients included in the study are described in with criteria including, Age as Characteristics feature, Residence type, Risk factor and Gender. Polymorphisms in the HBV patients revealed the presence of the polymorphism in IFNGR gene at chromosome 6 in position 137219896+137219995 among 47% of patients compare with healthy group 21%. Study of HBV with healthy group against other test genes revealed a marked significance in the IFN-γ genes. There was a strong association of the IFN-γ at chr12:68158673-68158792 with HBV compare with healthy controls 61.4% and 27.08% respectively. Profile of gene Expression with IL28B Genotype revealed that (19.6%) patients with CC genotype, (71.6%) with CT (patients) and patients (8.8%) with TT genotype among chronic viral hepatitis B patients. Conclusions: Our study provided much important information concerning hepatitis B prevalence and risk factors.

Keywords: Iraq, Hepatitis C, Prevalence, General population, Risk factors, Blood donors, CD4+ and CD8+, IFNGR, IFN-?, IL-28B gene.


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