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Abstract

ANALGESIC ACTIVITY OF SOLENOSTEMMA ARGEL BY MODULATING PAIN NOCICEPTION PATHWAY IN MICE

*Mahmoud M. E. Mudawi, Vijay R Chidrawar, Abdelhadi Y.A. Yassin, Rami S. Habeballa, Mohammed F. Abd E l-wahab, Mansour I. Sulaiman

ABSTRACT

The present study aims to investigate the centrally and peripherally acting analgesic activity of the aqueous extract of Solenostemma argel (AESA) in mice by using Eddy’s Hot plate and acetic acid induced writhing model respectively. The extract was administered per orally at dose of 10 ml/kg and 20 ml/kg while diclofenac sodium was used as standard for both the models. In hot-plate model, the AESA exhibited significant analgesic activity by increasing the reaction time compared to distilled water treated group. Diclofenac Sodium considered as a mild analgesic and showed analgesic effect but not significantly in this study. In comparison with control group 20 ml/kg AESA has shown most significant (P<0.05) anti-nociception effect during 60 min and 90 min observation, while 10 ml/kg AESA showed significant effect only at 90 minutes. The AESA exhibited significant analgesic activity at both the doses against acetic acid induced writhing model (P<0.05) by reducing the number of writhes, the percent inhibition was 43.27% & 21.04% respectively. The reference drug diclofenac sodium was found more potent (44.71%) than both the dose levels of plant extracts. Surprisingly 10 ml/kg dose of the plant extract has shown better protection than 20 ml/kg. The administration of acetic acid intraperitoneally activates both peripheral and central mechanisms of pain because of nociceptive mediators such as prostaglandins (PG) E2 and I2 at the site of noxious stimulation. The major constituents of the Solenostemma argel are tannins and saponines which comprises up to 60% of its total content may be responsible for its analgesic activity. In conclusion, the aqueous extract of Solenostemma argel displayed analgesic activity.

Keywords: Solenostemma argel, nociception, hot plate, acetic acid, phytochemistry.


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