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Abstract

INHIBITORY EFFECT OF A POLYHERBAL FORMULATION ON ?- GLUCOSIDASE, AND PORCINE PANCREATIC AMYLASE IN TYPEII- DIABETES.

Dr. K.S.Dayananda*, P. Jagan Mohan Reddy and Ajaymandal

ABSTRACT

Diabetes has become a common global health problem that affects >170million people worldwide. It is one of the leading causes of death and disability. It is estimated that by 2030, the number will rise to 366 million (www.who.int). The majority of diabetes (~90%) is type 2 diabetes (T2D) caused by a combination of impaired insulin secretion from pancreatic beta cells and insulin resistance of the peripheral target tissues, especially muscle and liver. Traditional Medicines obtained from medicinal plants are used by about 40-60% of the world’s population. Though there are many approaches to control diabetes and its secondary complications, herbal formulations are preferred due to lesser side effects and low cost. In the present study focused on screening of cinnamomum cassia extract for antidiabetic activity with respect to two different enzymatic assay as such α -glucosidase and α – amylase inhibition assay. It was reported by many researchers that diabetic patients are under oxidative stress due to an imbalance between the free radical generation and radical scavenging capacities. Therefore, use of antioxidants can be beneficial for diabetic patients. Further, the screening of cinnamomum cassia had been done using two antioxidant assay- ABTS & DPPH radical scavenging assay in in vitro. Extracts of cinnamomum cassia exerted in vitro inhibitory potential against α -amylase with IC50 ranging from 100.53 to170.70 μg/ml but shows no inhibitory effect against α -glucosidase. The antioxidant activities of the extract, measured in terms of IC50 values for ABTS and DPPH radical scavenging assay are 60.90-88.54 μg/ml and above 200 μg/ml, respectively. The above results support that the cinnamomum cassia has the ability to inhibit the enzyme alpha amylase and also acts as an antioxidants.

Keywords: Cinnamomum cassia DPPH ABTS Type 2 Diabetes.


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