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Abstract

DESIGN, FORMULATION AND EVALUATION OF A POLYHERBAL OINTMENT FOR ITS WOUND HEALING ACTIVITY

K. S. Dayananda*, Jagan Mohan Reddy and Ajay Mandal

ABSTRACT

Non-healing wounds are a significant problem in health care systems all over the world. Unlike other areas of health care, wound management need much attention for maximum benefit. During the last ten years different types of multidisciplinary concepts for the treatment of wounds have been created. A number of drugs ranging from simple non-expensive analgesics to complex and expensive chemotherapeutic agents administered in the management of wound. These drugs do not play major role in the wound healing process. The production and clinical evaluation of herbal remedies have made revolution in the use of traditional medicine with modern industrial venture rather than the use of raw herbal materials. On this basis, The present study was aimed at designing, formulating and evaluating a polyherbal ointment comprising of ethanolic extracts of the leaves of Azadirachta indica,, Leucas zeylancia Ocimum sanctum ,rhizome of Curcumalonga juice of calotropis gigantean and Aloe vera The parameters evaluated for wound healing were period of contraction and tensile strength using excision and incision models. The animals were divided into groups and were treated with polyherbal formulation, standard group and one served as control group. Nitrofurazone (0.2% w/w) was used as reference standard. The period of epithelization in the excision wound mode was found to be 13.50 days, while in case of incision wound model the tensile strength was 550 when compared to the controls ,the results were extremely significant. Different parameters like pH, viscosity, spreadability and stability were evaluated. The formulation showed good spread ability, good consistency, homogeneity, there was no change in the appearance, pH, and no phase separation noticed at the end of the stability studies. There was no evidence of skin irritation. This study has revealed that the poly herbal ointment has shown the wound healing effect due to the synergistic activity of the phytoconstituents present in the extracts and may be used a potential herbal formulation for wound healing.

Keywords: Azadirachta indica, Leucas zeylancia Ocimum sanctum, rhizome of Curcumalonga juice of calotropis gigantean and Aloe vera


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