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Abstract

SPECTROPHOTOMETRIC DETERMINATION OF PARACETAMOL AND DICLOFENAC IN COMBINED DOSAGE FORM BY SIMULTANEOUS EQUATION METHOD USING UV–VIS SPECTROPHOTOMETRY

*MD. azeez1, B.kiran kumar1, manoranjan sabat1, G.venkteshwarlu, G. shreesailam1, sujit Kumar patro2

Venkateshwara Institute of Pharmaceutical Sciences, Cherlapally, nalgonda, India.

ABSTRACT

A simple spectrophotometric method is developed for simultaneous estimation of paracetamol and diclofenac in bulk and pharmaceutical dosage form. Thepresent study was employed to determine the % purity of drugs in combined dosage form. The S.D. is found to be 0.0375 and the%RSD is found to be 1.299%. The method is validated according to ICH guidelines. From data generated in this method it was revealed that the method is precise, accurate and sensitive. Literature review reveals that a there is no suitable method for determination of this combined dosage form. This simple UV method is followed to determine the %purity of the combined dosage form. By this procedure the analysis of the components were done without prior separation and without interference of excipients. For the analysis of components by simultaneous estimation method two wavelengths are selected one is λmax of paracetamol i.e. 247nm and other one is λmax of diclofenac i.e. 280nm. The developed method was successfully applied for routine analysis of drugs.

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