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Abstract

FORMULATION AND EVALUATION OF DEXIBUPROFEN MATRIX TABLETS FOR ORAL CONTROLLED DRUG DELIVERY

Manjanna K. M.*, Rajesh K.S and Pramod Kumar T. M.

ABSTRACT

Dexibuprofen[S (+)-Ibuprofen] is used in the symptomatic treatment for osteoarthritis, muscular pain and inflammation. The purpose of the present research work was to develop controlled release matrix tablets of dexibuprofen by direct compression technique using different concentrations of hydroxyl propyl methyl cellulose (HPMC-K15M) Kollidon SR (Polyvinyl acetate & povidone) as polymers and Pharmatose 200M as diluent. The drug excipients mixtures were subjected to preformulation by FTIR, DSC and XRPD studies. The different in-process and finished product quality controlled tests of the formulations were evaluated and found within the pharmacopeias limits In-vitro drug release was estimated in simulated gastric fluid (SGF) pH1.2 for initial 2h, shows ≤ 20% w/w and simulated intestinal fluid (SIF) pH 7.4 > 60 %w/w followed by sustaining up to 12 h. The swelling behaviors of formulated tablets remarkably increase with optimum proportion of polymer and diluent level. Based on the invitro dissolution data the optimized formulations DX-4 and DX-9 were best fitted to huguchi matrix followed by Korsmeyer and Peppa‟s model, shows diffusion co-efficient values in between n=0.8306 and 1.1356, indicates the drug release from matrix tablets by both diffusion and erosion mechanisms controlled by diffusion of swellable thick polymeric gel layer matrices.

Keywords: Dexibuprofen, Oral controlled release, Matrix tablets, Kollidon SR, Higuchi matrix kinetics, Zero-order kinetics.


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