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Abstract

PARALLEL QUANTITATIVE ESTIMATION OF GALLIC ACID IN AQUEOUS EXTRACT OF EMBLICA OFFICINALIS AND POLYHERBAL DOSAGE FORM (CAPSULE) BY RP-HPLC TO ASCERTAIN THE AUTHENTICITY OF THIS INGREDIENT IN THE DEVELOPED FORMULATION.

A. Singh*, P. Raghaw A, B. Dwivedia, R. Singha, P. Panta, M.M.Padhia

ABSTRACT

In the present study Gallic acid is parallel quantified by optimized RPHPLC method in pharmaceutically developed poly-herbal dosage form (capsule) and aqueous extract of Emblica officinalis fruit to examine the authenticity of this ingredient in finished dosage form. The Chromatographic analysis was performed on Shimadzu 10AVP HPLC System using Phenomenex Luna C18 reverse-phase column (4.6 x 250mm, 5μ particle size). The mobile phase comprised of Water: Acetonitrile : Acetic acid(90 : 10 : 0.2 v/v) at a flow rate of 1.0 ml/min and 272nm as detection wavelength. The regression equation showed good linearity in the range of 0.5-50μg/mL for Gallic acid (R2 > 0.9997) between the peak areas of each marker and concentration. The retention time was 4.31min and the amount of gallic acid in aqueous extract and poly-herbal formulation of Emblica officinalis was found to be 14.17%w/w and 1.95%w/w respectively.

Keywords: Emblica officinalis, Gallic acid, HPLC.


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