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Abstract

BACTERIAL ENDOTOXIN TEST FOR CERTAIN PHARMACEUTICAL COMPOUNDS

P.Jyothi Chaitanya, R.Chandrashekar, and N.Lakshmi Bhavani*

Department of Botany, University College of science, Saifabad, Osmania University, Hyderabad, Andhra Pradesh, India

ABSTRACT

Endotoxins are Lipopopolysaccharide 1complexs associated with the cell wall of the gram negative bacteria such as E.coli, Salmonella, Pseudomonas, Heamophilus and other pathogens. Antibiotics with endotoxin contamination can cause pyrogenic effects in patients when treated with these antibiotics. In order to prevent the side effects of the endotoxin contamination antibiotics have to be thoroughly tested for endotoxins. LAL method is one of the endotoxin estimating method that is used in some pharmaceutical industries to test their end products for free of endotoxins. In bulk sterilization process of drugs in pharmaceutical industries, LAL method is the method for detection of endotoxins that is widely used to test antibiotics. In present investigation products like the pharmaceutical compounds cloxillin sodium sterile, sulbactum sodium sterile, ceftriaxone sodium sterile, piperacillin sodium sterile, amoxicillin sodium sterile are tested for the endotoxins.

Keywords: Endotoxins, Gram-negative bacteria, Pharmaceutical compounds.


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