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Abstract

ISOLATION AND PARTIAL CHARACTERIZATION OF POTENT SPONGE DERIVED ACTINOMYCETES AGAINST MULTIDRUG RESISTANT BACTERIA

Sunanda Kumari Kadiri*, Nagendra Sastry Yarla and Siddaiah Vidavalur

ABSTRACT

The present study aimed to investigate the antimicrobial activity of
sponge derived actinobacteria against multidrug resistant pathogenic
strains. Forty actinobacterial strains were isolated from five sponges
belonging to the class demospongiae isolated along the Andhra Coast.
Potential colonies were purified and stored. Primary screening was
done using cross-streak method against pathogenic bacteria. Isolates
with antagonistic properties were biochemically characterized and
inoculated into production media for secondary metabolite extraction.
The antimicrobial activity of crude and solvent extracts was performed
using Kirby-Bauer method. The six actinomycete strains showing
maximum antibacterial activity were isolated further characterized
based on their colony characteristics and bioichemical analyses. The
ethyl acetate extracts showed high inhibition against the two pathogenic bacteria tested
methicillin – Resistant Staphylococcus aureus (S. aureus) and vancomycin-resistant
Enterococci (VRE). The results of the current investigation show a high diversity of
actinomycetes associated with marine sponges as well as highlight their potential to produce
new drugs molecules.

Keywords: Actinomycetes, Marine Sponges, Antibacterial activity, Multidrug resistance.


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