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Abstract

VALIDATED RP-HPLC METHOD FOR THE ESTIMATION OF VALGANCICLOVIR IN BULK AND TABLET DOSAGE FORM

M.Lakshmi Surekha*, G.Kumara Swamy

Department of Pharmaceutical Analysis, Trinity College of Pharmaceutical sciences, Peddapalli, Karimnagar (dist) - 505172.A.P.

ABSTRACT

A simple, selective, linear, precise and accurate RP-HPLC method was developed and validated for rapid assay of Valganciclovir (valganciclovir) in bulk and in tablet dosage form. Isocratic elution at a flow rate of 0.6ml/ min was employed on a Phenomenax Luna C18 column (150  4.6mm; 5) at ambient temperature. The mobile phase consisted of Potassium di hydrogen phosphate buffer (pH-4.5) and acetonitrile in the ratio 45:55. The PDA detection wavelength was 254 nm and 20 l of sample was injected. The retention time for valganciclovir was 3.76 min. The method obeys Beer's law in the concentration range of 20-60 g/ ml. The amount of Valganciclovir Present in the formulation was found to be 99.60  1.5389. The % recovery was in the range between 99.25% and 99.86%. The percentage RSD for precision and accuracy of the method was found to be less than 2 %. The method was validated as per the standard analytical procedures and statistical parameters. The method was successfully applied for routine analysis of valganciclovir in bulk and in formulation.

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