WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60


Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here


Track Your Article



R. S. Cheke, P. R. Todkari, N. P. Sawadadkar*, V. J. Chaware, K. R. Biyani


Phenobarbital is most commonly used antiepileptic drug. But most of patient suffers from the side effects of Phenobarbital. For the safety and efficacy of this drug it is necessary to identify the adjuvant therapy that could increase the therapeutic effect. One potential therapy is Alpha Lipoic Acid. Alpha Lipoic Acid is a biologic antioxidant which also used to decrease the oxidative stress produced in epilepsy. The main aim of present study to potentiate the antiepileptic activity of Phenobarbital and also reduced the dose of Phenobarbital in such a way that that could not affects its therapeutic benefit with the alpha lipoic acid which is used as adjuvant. The reduced dose of Phenobarbital could reduces the side effects. In these study all the animals were divided into sixteen groups & each groups consist of six animals. All group received PTZ (65mg/kg i.p.). Mice were pre treated with Phenobarbital and alpha lipoic acid. Testing drugs doses were randomised within groups of animal such that each group was required during a given test series. The pharmacological screening shows that Phenobarbital, co-administration of Phenobarbital & alpha lipoic acid significantly increased latency to clonic convulsions & reduced mortality in PTZ treated. Also alpha lipoic acid, Phenobarbital combination treatment decreased serum MDA activity. It is concluded that alpha lipoic acid potentiates the anti epileptic activity of Phenobarbital in mice. Alpha lipoic acid, Phenobarbital in combination decreased oxidative stress and prevents epilepsy also the reduced dose of Phenobarbital causes reduction in side effects.

Keywords: ALA, PTZ, PB, Seizures, MDA.

[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More