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Abstract

DESIGN, SYNTHESIS, AND PHARMACOLOGICAL EVALUATION OF NEW AZITIDIN 2-ONE DERIVATIVES.

Pinka A. Patel and Pankaj S. Patel*

ABSTRACT

A new series of 3-chloro-4-{4-[2-{5-(4-chlorophenyl)-3-(4-methoxy phenyl)-4,5-dihydro-pyrazol-1-yl}-2-oxoethoxy]phenyl}-1- (substitutedphenyl)azetidin-2-one derivatives has been synthesized and subjected to evaluate their antimicrobial activity. All the synthesized compounds of the series elicit remarkable activity in comparison to standard drug. Structures of the synthesized compounds have been elucidated on the basis of their elemental analyses and spectral data.

Keywords: azetidinones, ?-lactams, antimicrobial, DMSO.


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