WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

DESIGN AND DEVELOPMENT OF PHYTOSOMES CONTAINING METHANOLIC EXTRACTS OF NYMPHAEA NOUCHALI AND TRICHOSANTHES DIOICA

A. Sumathi* and R. Senthamarai

ABSTRACT

Phytosome represents a promising vesicular drug delivery system to deliver therapeutic compounds for a wide range of possible applications. Nymphaea nouchali (Nn), Indian Red Water Lily, is a water lily of genus Nymphaea. It is considered as a medicinal plant in Indian Ayurvedic medicine under the name Ambal; it was mainly used to treat indigestion and various ailments. Trichosanthes dioica (Td), cultivated widely in eastern India, has been used for overcoming problems like constipation, fever, skin infection, wounds, abdominal disorders and leprosy. Phytosome is obtained by reacting phosphatidyl ethanolamine (PE) in tetrahydrofuran with the selected botanical derivatives in dioxane:methanol (7:3) solvent system. Different Nn/Td:PE molar ratios (1:1, 1:2, 1:4, 1:6, 1:8 and 1:10) were employed using solvent evaporation technique. In vitro appraisal encompassed differential calorimetry, infra red spectroscopy, particle size, drug content, diffusion and stability studies. The results revealed that the optimized phytosomal carriers, PE(Nn/Td) exhibited the mean particle size of 268 nm and good in vitro stability in the ratio of 1:8. It also exhibited significant enhancement in diffusion rate compared to crude drug mixture and standard (Levimasole). Thus, the phytosomal carrier (PE) with 89 % of entrapped drug could be successfully tailored for Nn/Td with improved in vitro release characteristics which is promising for increasing drug delivery and decreasing the effect of exogenous factors.

Keywords: Nymphaea nouchali, phosphatidyl ethanolamine, phytosomes, Trichosanthes dioica.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More