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Abstract

ANTIARTHRITIC ACTIVITY OF HYDROALCOHOLIC EXTRACT OF LEAVES OF AMARANTHUS TRICOLOR IN FREUND’S COMPLETE ADJUVANT- INDUCED ARTHRITIS IN WISTAR RATS

Gopal V. Bihani*, Parag P. Kadam, Subhash L. Bodhankar

ABSTRACT

The objective of the study was to evaluate antiarthritic activity of hydroalcoholic extract of Amaranthus tricolor L. (HAEAT) in Freund’s complete adjuvant (FCA) induced arthritis in female Wistar rats. HAEAT was prepared by maceration and subjected to preliminary phytochemical screening and tested against FCA induced arthritis in rats. Arthritis assessment was done by measuring- paw volume, joint diameter, body weight, arthritis score, pain threshold, thermal hyperalgesia, haematological and biochemical parameters. The HAEAT was administered at the concentrations of 100, 200 and 400 mg/kg body weight. HAEAT (200 and 400 mg/kg) significantly (p<0.01 and p<0.001, respectively) decreased paw volume, joint diameter and increased pain threshold, body weight and paw withdrawal latency compared to arthritic control group. HAEAT (200 and 400 mg/kg) exhibits significant (p<0.01 and p<0.001, respectively) antiarthritic activity by increasing the haematological parameters like red blood cell (RBC), haemoglobin (Hb) and decreasing the white blood cell (WBC), platelets and serum C-reactive protein (CRP). The levels of aspartate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatase were decreased and the level of total protein was increased by treatment with HAEAT (200 and 400 mg/kg). The present study suggests that HAEAT has antiarthritic potential, and it might be attributed to the phytoconstituents such as tannins, flavonoids and phenolic compounds present in the extract.

Keywords: Amaranthus tricolor L, Rheumatoid arthritis, Freund’s complete adjuvant, Antiarthritic.


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