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Abstract

AN EXPERIMENTAL STUDY TO ASSESS THE SYSTEMIC AND DERMAL TOXICITY OF BIODEGRADABLE DERMAL PATCH FOR WOUND HEALING

Awadhesh Kumar Pandey*, Pathak Meenakshi S.N., Prof.M.Sahu, Dr.Vijay Kumar

ABSTRACT

Background: A wound may be defined as a break in the epithelial integrity of the skin or may also be defined as a loss or breaking of cellular anatomic or functional continuity of living tissue. Several indigenous drugs have been mentioned for the beneficial effect of wound healing activity in ancient Ayurvedic classics, especially Sushruta Samhita. Group of barks of five trees as Vata (Ficus bengalensis Linn.), Udumbara (Ficus glomerata Roxb.), Ashwatha (Ficus religiosa Linn.), Plaksha (Ficus lacor Buch-Ham.) & Parishpippal are together known as “Panchavalkala” and mentioned in all Ayurvedic classics. Panchvalkal is reported in different Ayurvedic classics to be used for wound healing. Parishpippal as described in Nighantu granthas,is interpreted by Dalhan as Gardbhand and it is a controversial drug. So for the present Toxic study above four drug have been selected containing Aqueous Extract of four Ficus species i.e Compound Ayurvedic drug(CAD). Objective: The objective of this study is to evaluate the Systemic and Dermal toxicity of Compound Ayurvedic drug(CAD) impregnated in Poly (lactic acid) (PLA-CAD) polymer according to the Organisation for Economic Co-operation and Development (OECD) 404 guidelines. Materials and methods: Wister Albino Rats were used for Excisional wound model and divided in to two groups. In Group I, according to OECD 404 guidelines, the test substance i.e., Compound Ayurvedic drug was impregnated in Poly (Lactic Acid) (PLA-CAD) polymer and applied in small area (approximately 1 cm2) of skin. Bio degradable patch was attached to the skin in such a manner that there should be a good contact and uniform distribution of the patch on the skin. In Group II, the untreated skin areas of the test animal served as the control and dressing was done with only Normal Saline. Results: No mortality, abnormal behavior and body weight differences were found after 2 weeks of PLA-CAD bio degradable patch dermal exposure in Group I. No obvious dermal toxicity was observed to PLA-CAD bio degradable patch during the entire 14-day Dermal exposure. No toxicological changes were seen on 14th day in liver, spleen and kidney in histopathological examination. Conclusions: These findings suggested that the compound Ayurvedic drug(CAD) impregnated in poly (lactic acid) (PLA-CAD) polymer had no Systemic and Dermal toxic effect as observed in excisional wound model of Wister Albino Rat.This justifies that the compound ayurvedic drug is safe if applied on different kinds of wound.

Keywords: dermal patch, excisional wound model, OCED guidelines, toxicity, Poly (lactic acid).


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