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Abstract

EFFECTS OF SOME ANTIHISTAMINES ON RAT PLASMA ACID PHOSPHATASE AND LACTATE DEHYDROGENASE ACTIVITY.

*Okwandu, Ngozika, Ifemeje, Jonathan and Modo Emmanuel

ABSTRACT

The antihistamines: Piriton, cypron, and Tavagyl are among the most common group of H1- antagonist used to manage cellular responses caused by histamine release in Nigeria and like any other drug, they have some side effects at therapeutic doses and toxic doses. The effects of the antihistamine piriton, Cypron, and Tavagyl on the activities of plasma Acid phosphatase (EC.3.1.3.2), and lactate dehydrogenase (EC.1.1.1.27) of rat were determined at an optimum Temperature of 370c pH 6.0, and 370c pH 8.0. Piriton, Cypron, and Tavagyl were found to increase Acid phosphatase activity. For instance, at maximum piriton, cypron, and Tavagyl dose of 0.04mg/ 300g body weight, and 30 days duration, ACP activity increased by 65.33±0.88% (P>0.05), 69.67±0.33% (P<0.05) and 79.67± 0.33% (P<0.05) respectively. In vitro, piriton, Cypron, and Tavagyl concentrations of 0.04mg/ml caused an increase of 49.00±0.38%, 52.60±0.43%, and 57.00±67% respectively in human plasma Acid phosphatase activity. However, piriton, cypron, and Tavagyl caused a decrease in lactate dehydrogenase (P<0.05). At an optimum piriton cypron, and Tavagyl dose of 0.04mg/ 300g body weight, the LDH activity decreased to 23.67±0.33%, 33.00±0.58%, and 38.67±0.33% within 30 days duration of the test repetitively. In vitro LDH decreased to 32.33± 0.33%, 32.00±0.58%, and 33.67±0.67% at piriton, cypron, and Tavagyl concentration of 0.04mg/ml respectively. These findings would be of relevance in clinical diagnosis involving these enzymes as well as metabolic processes mediated by the same.

Keywords: Piriton, Cypron, Tavagyl, plasma Acid phosphatase, plasma Lactate dehydrogenase, Rat.


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