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Abstract

IN-VITRO MEMBRANE STABILIZING ACTIVITY OF DIFFERENT EXTRACT OF BAHINIA TOMENTOSA (L.) LEAVES

V.Kalaiselvi, R.Vidhya*

ABSTRACT

Bahinia tomentosa leaves are important medicinal plant with several
ethnomedicinal properties. In this study different extracts (aqueous,
methanol and ethyl acetate) of leaves of B. tomentosa were screened
for phytochemical analysis and membrane protection against human
erythrocytes (RBC). Phytochemical screening of the leaves of B.
tomentosa showed the presence of phytosterols, glycosides, phenolic
compound, saponins, alkaloids, flavonoids and tannins as major
phytocompound present in all the extracts. To confirm the membrane
stabilizing/protection activity of B. tomentosa was observed by
hypotonic saline and heat induced hemolytic method. The aqueous
extract of B. tomentosa leaf showed very less hemolytic activity in
hypotonic saline induced hemolysis when compared to other two
extracts. The maximum membrane protection of RBC was observed in
the aqueous extract of leaf of B. tomentosa at concentration 500μg/ml, which has been
compared to standard drug Diclofenac sodium (1mg/ml). In future recommend further in
vitro and in vivo studies to evaluate the clinical efficacy of B. tomentosa leaf extract for
treated various disease conditions.

Keywords: Bahinia tomentosa, hemolytic activity, membrane stabilization, aqueous, methanol, ethyl acetate.


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