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Abstract

CHEMICAL COMPOSITION AND ANTIMICROBIAL ACTIVITIES OF THE ESSENTIAL OIL OF WILD ALGERIAN MARRUBIUM VULGARE L

*O. Chouitah1, B. Meddah1, A. Aoues 2, P. Sonnet3

1BGSS Laboratoire engineering and health Security University de Mascara - 29000, Algeria
2 Laboratoire de Biochimie Faculté des Sciences, Université d’Oran - 31000 Algérie
3UMR-CNRS 6219, Laboratoire des glucides, UFR de Pharmacie, Université de Picardie Jules Verne, 1 rue des Louvels, Amiens, 80037, France
Centre National pour la Recherche Scientifique et Technique (CNRST) - RABAT Maroc.

ABSTRACT

This study describes the chemical composition and antimicrobial activity of essential oil of Marrubium vulgare growing wild in Mascara region. This plant is very used in Algeria and widely used by local people for its medicinal properties. We proposed to determine the physicochemical, organoleptic and chemical identification of these components. The essential oil from the leaves of Marrubium vulgare was obtained by hydrodistillation and analyzed by GC and GC/MS . Other parameters such as refractive index, optical rotation; density, polarimetric deviation;freezing point and Solubility in ethanol are also measured. 99,01% of the total peak areas were identified. The main constituents of the essential oil were the hydrocarbon and oxygen compounds: Sulfamethoxypyridazine n 14.44%, Eugenol 10,50%,o- Undecylenic Acid 10,48% _-Citronellol 9,78% ,Silvex8,38% ,Germacrene-D 8,21,pinene 7,30% Carbromal4,87%.The antibacterial activity of the oil was determined using the agar diffusion method and it was found that it was active against Escherichia coli (ATCC 25923), Salmonella typhimurium ATCC14028), Staphylococcus aureus (ATCC-29213) ,Bacillus subtilis (ATCC-6633) ,Escherichia coli (G-)( ATCC (35218) and Pseudomonas aeroginosa (ATCC 27853).

Keywords: Marrubium vulgare, Essential oil, antimicrobial activity, GC/SM.


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