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Abstract

ROLE OF ZINC ON 131I UPTAKE STUDIES IN ETHANOL ADMINISTERED RATS

R Pathak, D Dhawan and A Pathak*

ABSTRACT

Background and objective: Zinc is a powerful antioxidant and an essential trace element which plays important role in treating the adverse effects of alcohol intake. Therefore, present study was aimed at investigating the effect of zinc under such conditions in thyroid to see whether zinc has positive role to play under alcoholic conditions. Methods: To evaluate the role of zinc on thyroid under conditions of ethanol toxicity, 131I uptake was studied after 2, 4 and 8 weeks of different treatments. Male Wistar rats were divided into four main groups viz. normal control, ethanol treated, zinc treated and zinc +ethanol treated group. 3 ml of 30% ethanol was given orally to ethanol and zinc+ethanol treated animals daily for different time intervals. Zinc was given in the form of zinc sulfate (ZnSO4.7H2O) at a dose level of 227 mg/L mixed with drinking water of the animals. Results: Ethanol feeding resulted in an increase in 2 hour and 24 hour thyroidal 131I uptake and decrease in biological and effective half lives of 131I, while zinc supplementation tend to normalize the uptake as well as the biological half life of 131I. Interpretation and Conclusion: Zinc supplementation, at a dose level of 227mg/L mixed in the drinking water of the animals, could restore the above mentioned parameters which were altered under ethanol intoxication. Therefore, it appears that zinc has somewhat protective potential in normalizing some of the damage caused in thyroid functions following ethanol administration.

Keywords: Zinc; ethanol; 1-131 uptake.


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