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Abstract

Q-ABSORBANCE RATIO METHOD FOR SIMULTANEOUS ESTIMATION OF CILOSTAZOL AND IMIPRAMINE IN COMBINED DOSAGE FORM

Paras M. Brahmbhatt*, Laxman M. Prajapati, Amit K. Joshi, Mohammadali L. Kharodiya

ABSTRACT

The present manuscript describes simple, sensitive, accurate, precise
and economical Q-absorbance ratio method for the determination of
cilostazol and imipramine in combined dosage form. Absorbance ratio
method uses the ratio of absorbances at selected wavelengths, one
which is an isoabsorptive point and other being the λ-max of one of the
two components. Cilostazol and imipramine show an isoabsorptie
point at 233.400 nm in methanol. The second wavelength used is 258
nm, which is the λ-max of cilostazol in methanol. The linearity was
obtained in the concentration range of 10-35 μg/ml for cilostazol and
imipramine.

Keywords: Cilostazol, imipramine, absorbance ratio method, isoabsorptive point, simultaneous


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