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Abstract

A NOVEL LCZ696 DRUG THERAPY VERSUS ENALPRIL IN THE TREATMENT OF HEART FAILURE

Niraj Khatri Sapkota*

ABSTRACT

LCZ696 (sacubitril valsartan) is a first-in-class angiotensin receptor
neprilysin inhibitor that has been developed for the use of heart
failure correspondingly neprilysin is an enzyme that contributes to the
breakdown of the biologically active natriuretric vasodilator peptide
(ANP) and several other vasoactive compounds. Neprilysin inhibitor
has been proved to be a therapeutic target for several compounds that
have been tested in cardiovascular disease. Although ecadotril,
candoxatril, and omapatrilat were initially tested in hypertension
and/or heart failure, lack of efficacy and side effects led to
discontinuation of their development. LCZ696 is a compound
composed of 2 molecular moieties in a single crystalline complex, the angiotensin receptor
blocker valsartan and a neprilysin inhibitor, pro-drug phase 2 trial in heart failure with
preserved ejection fraction which demonstrated greater efficacy than enalapril in a phase 3
trial in heart failure with reduced ejection fraction, therefore LCZ696 posses superior efficacy
in the management of heart failure compared to the enalpril by decreasing the rate of
morbidity and mortality and its mechanism is to inhibit or suppress the renin- angiotensinaldosterone(
RAAS) axis and augment the endogenous natriuretic peptide system.

Keywords: LCZ696,Neprilysin,Enalpril, Heart failure.


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