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Abstract

DESIGN, EVALUATION AND ASEPTIC REFINER TECHNIQUES FOR MICROSPHERE FORMATION

Omprakash G. Bhusnure*, Chandrakant A. Shinde, Sachine B. Gholve, Nitin Shinde, R.V.Sugave, R.M. Rajurkar and Padmaja S. Giram

ABSTRACT

With advances in biotechnology, genomics and combinational chemistry, a wide variety of new, more potent and specific therapeutics are being created. There are various departments of medicine like cancer, pulmonary, cardiology, radiology, gynaecology, and oncology etc, numerous drugs are used and they are delivered by various types of drug delivery system. Among them microspheric drug delivery system has gained enormous attention due to its wide range of application as it covers targeting the drug to particular site to imaging and helping the diagnostic features. Because of common problems such as low solubility, high potency and/or poor stability of many of these new drugs, the means of drug delivery can impact efficacy and potential for commercialization as much as the nature of the drug itself. Thus there is a corresponding need for safer and more effective methods and devices for drug delivery. Indeed drug delivery system should be designed to provide a therapeutic agent in the needed amount, at the right time to the proper location in the body, in a manner that optimizes efficacy, increases compliance and minimizes side effects. Among a wide variety of devices that have been used for controlled drug delivery, microspheres are one of the most common types and hold several advantages. The microspheres are characteristically free flowing powders consisting of proteins or synthetic polymers, which are biodegradable in nature, and ideally having a particle size less than 200μm. Solid biodegradable microspheres incorporating a drug dispersed or dissolved throughout particles matrix have the potential for the controlled release of drug. The objective of this article is to emphasize on the principles underlying the development and evaluation of microspheres as a controlled and targeted drug delivery system as well as details information regarding its mechanism of drug release, evaluation techniques, advantages, applications & challenges encountered by pharma manufacturers when formulating.

Keywords: Microspheres, Characterization, Mechanism of release, Evaluation, Challenges Drug Delivery.


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