WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

BEHAVIORAL AND BIOCHEMICAL EVALUATION OF ANTIAMNESIC ACTIVITY OF ACACIA AURICULIFORMIS LEAF EXTRACT IN RATS

Shetty MS, Yadav Kameshwar, Shenoy S, Bhandarkar AP*, Vaishnav RL, Shenoy GK

ABSTRACT

Background: Alzheimer’s disease (AD), the most common cause of progressive dementia in the elderly, is a chronic neurodegenerative disorder that leads to disturbances of cognitive functions. The effects and benefits of Acacia auriculiformis (AA) on health are not well established. Aim of the study: This study was planned to evaluate the protective effect of ethanolic extract of Acacia auriculiformis leaves against scopolamine-induced memory loss using learning and memory model in rats. Materials and Methods: Twenty four adult male albino rats were divided into 4 equal groups. Memory retention performance of rats was evaluated using Morris’ water maze after oral administration of two different doses (200 mg/kg and 400 mg/kg) of ethanolic extract of Acacia auriculiformis with rivastigmine 5 mg/kg as positive control and 1% Tween-80 p.o. to the normal control group for 45 successive days. On the last day of treatment, a single i.p injection of scopolamine 3 mg/kg was administered one hour after the test agent administration and 20 minutes prior to water maze test. Post behavioral testing, the animals were sacrificed and brain cholinesterase activity was estimated to substantiate the findings of behavioral test. Data was analyzed using one way Analysis of Variance (ANOVA) followed by Tukey’s post-hoc test using GraphPad Prism software, version 6.01. Results: The AA extract exhibited a dose-dependent improvement in memory retention performance in rats with scopolamine-induced dementia tested on water maze model. Dose-dependent inhibition of brain cholinesterase activity (P < 0.001) was also noted in extract-treated groups. 400 mg/kg AAE group showed much superior results than rivastigmine in all four parameters of water maze like target quadrant entry (P < 0.001), island entry, escape latency and total time spent in target quadrant (P< 0.05), and also in AChE inhibitory activity (P< 0.001).There was no significant difference between 200 mg/kg AAE and rivastigmine groups in both behavioral and biochemical tests. Conclusion: It is evident that acetylcholinesterase inhibiting property of Acacia auriculiformis is the most likely contributor for its anti-amnesic activity. Further well-designed large scale studies are required to clearly elucidate its benefits as well as safety in humans. In future this may offer a promising novel option for the treatment of dementia disorders.

Keywords: Acacia auriculiformis, acetylcholinesterase, water maze, Alzheimer’s disease


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More