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Abstract

HOMOCYSTEINE AND LIPOPROTEIN ? ROLE IN NON-DIABETIC OBESE AND NON OBESE SUBJECTS WITH CARDIOVASCULAR DISEASE

B.Madhusudhana Reddy, S.Vijaya and M.Prasad Naidu*

ABSTRACT

Obesity has become one of the major health problems in advanced society. The Prevalence rate of overweight and obese in India is 12.8percent and 10.3 percent respectively obese. For this intensive study, initially 200 Volunteers those who were undergoing treatment for cardiovascular disease were selected. Glucose was estimated by the Glucose Oxidase and Peroxidase method. Human Analyzer kits to analyze Total cholesterol, triglycerides and HDL, VLDL and LDL. Homocysteine was estimated enzymatically by Block and kredich method. The result shows Lipoprotein α of non obese subject showed a significant (p<0.001) increase than in the obese subject. The level of HDL-C showed a significant decrease (P<0.0010) in obese when compare to non obese subjects. The LDL-C and VLDL-C fractions showed and significant increase (P<0.001). out of 30 subjects 16 subjects showed the presence of Homocysteine in the blood plasma shows P<0.001 significant. The level of lipid ratio (Total cholesterol / HDL – C) was significantly high in obese subjects than in non obese subjects. The level of lipoprotein a in non-obese subjects was high when compared to obese subjects. The level of homocysteine was absent in obese subjects and moderately present in the non obese subjects.

Keywords: Homocysteine, Lipoprotein A, Lipid Profile, Obese And Cardiovascular Disease.


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