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Abstract

FABRICATION OF ACECLOFENAC MICROCAPSULES TO ACHIEVE HIGH ENTRAPMENT EFFICIENCY WITH SITESPECIFIC DELIVERY USING A 24 FULL FACTORIAL DESIGN

Manidipa Debnath*1, Dr. Y. Indira Muzib1, S. Ashutosh Kumar2

1Department of pharmaceutics, Sri Padmavathi Mahila University, Tirupati, Pin-17502. Andhra Pradesh, India.
2 A.K.R.G. College of pharmacy, Nallajerla, W.G. dist, A.P-534112, India.

ABSTRACT

As part of research program to investigate the controlled and targeted delivery of drug to the colon, an attempt was made to design Aceclofenac microcapsules by emulsion polymerization technique using Glutaraldehyde as a cross-linking agent. A 24 full factorial design of experiments was run to optimize the concentration range of formulation ingredients responsible for better entrapment efficiency as well as to provide maximum drug concentration after 6 to 8 hours of lag time until it reaches to colon. The microcapsules were characterized for Entrapment efficiency(12-74.5%), particle size (65- 525μm), % yield (52-90%),shape (Spherical), surface morphology (porous), FT-IR analysis (No Drug-Polymer interaction).The Entrapment efficiency of the optimized formulations were greater than 75% w/w. The In-vitro dissolution study of the optimized formulations (Fopt1, Fopt2.Fopt3) showed that drug release was independent of GI pH. The %drug release at pH, 1.2, 4.5, 6.0, 6.8, 7.2 buffer without enzymes were less than 10%. The %drug release at pH 6.8 enriched with α- galactosidase & galactomannase enzymes 86% within an hour. While at pH 7.2 with enzymes release was greater than 92% within an hour. The improved entrapment efficiency and drug release pattern were justifying the desire aim of the program.

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