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            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
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Shazia Alam*, Prof.Baqir.S.Naqvi and Sidra Alam


Objective: The study aimed was to evaluate the recent trends of drug utilization in hospitalized patients with unstable angina/Non ST elevated myocardial infarction (UA/NSTEMI) in a tertiary care hospital of Karachi, Pakistan. Method: A prospective observational study was carried out over a period of six months from July to December 2014 at multiple cardiology wards of tertiary care hospital located in Karachi, Pakistan. Research proposal was approved from ethical committee of Institution to accomplish the study. Drug utilization data of anticoagulants, anti-platelets, anti-hypertensive, angiotensin receptor blocker and concurrent use of medications such as anti-diabetic and lipid lowering agents was recorded from patient’s profile. Results were analyzed through descriptive statistics using SPSS version 20. Results: A total of 177 consecutive prescriptions were evaluated and drug utilization of medicines recorded during hospitalization were anticoagulants 100% (enoxaparin 86%, fondaparinux 14%), anti-platelets 95.5% (aspirin 79.7%, clopidogrel 15.8%), antihypertensive agents 88.6% including beta blockers 61.5% (metaprolol 28.8%, atenolol 22%, propranolol 10.7%) and calcium-channel blockers 27% (verapamil 15.8%, diltiazem 11.3%), angiotensin receptor blockers 59.3% (valsartan 26.5%, irbesartan 18.6%, losartan 14.1%) followed by lipid lowering agents 62.7% (atorvastatin 58.2%) and anti-diabetics 26.6%. Enoxaparin was one of the anticoagulant used by 86% of all patients for this indication. Conclusion: The drug utilization study assessed the use of different concomitant medications but enoxaparin has found to be the most widely used anticoagulant and the majority of health care practitioners recommend enoxaparin in combination with different drugs in the management of unstable angina/NSTEMI.

Keywords: Drug utilization, Unstable angina/NSTEMI, Enoxaparin.

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