WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

BIOACTIVE FRACTIONS AND POLYPHENOLS OF THE ETHANOL EXTRACT OF SWIETENIA MAHOGANI LEAVES

Ola Mohamed Mousa*, Marwa Yousry Issa, Hesham Ibrahim El-Askary, Soheir Mohamed El Zalabani and Amani A. Sleem

ABSTRACT

The ethanol (90%) extract of Swietenia mahogani L. Jacq. leaves was
fractionated with solvents of increasing polarities. The antioxidant and
hepatoprotective activities of all successive extractives were evaluated.
The highest efficiency was, in most cases, observed for the ethyl
acetate-soluble fraction. Repeated column chromatography of this
fraction and sub-fractions derived therefrom, on different stationary
phases (Polyamide and Sephadex LH-20), allowed the isolation of six
known polyphenols, previously unreported in the genus. Isolated
compounds namely: (+) catechin, quercetin-3-O-β-D-glucopyranoside
(isoquercitrin), 3-caffoeylquinic acid (neochlorogenic acid), quercetin-
3-O-β-D-galactopyranoside (hyperoside), quercetin and kaempferol
were identified through physico-chemical and spectral analyses and by
comparison with published data. The antioxidant activity of the three
first isolates was also assessed and found significant.

Keywords: Swietenia mahogani, leaves, antioxidant, hepatoprotective, polyphenols.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More