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Abstract

INSULIN RESISTANCE DECREASED DURING TREATMENT IN POLYCYSTIC OVARY SYNDROME (PCOS) WOMEN

Luma Qasime Ali*, Noori Muhammed Luaibi and Bushra Jawad majeed

ABSTRACT

Polycystic ovary syndrome (PCOS) is a highly prevalent endocrinemetabolic disorder that implies various severe consequences to female health, including alarming rates of infertility. Although its exact etiology remains elusive, it is known to feature several hormonal disturbances, including hyperandrogenemia, insulin resistance (IR), and hyperinsulinemia. Insulin appears to disrupt all components of the hypothalamus-hypophysis-ovary axis, and ovarian tissue insulin resistance results in impaired metabolic signaling but intact mitogenic and steroidogenic activity, favoring hyperandrogenemia, which appears to be the main culprit of the clinical picture in PCOS. material and method The study group which complete study period included (95) PCOS women(group A) include (35) women will treated with Metoformine for six months and (group B) include (32) women will treated with Choline &Inositol and Metoformine for six months and (group C) include (28) women will changed lifestyle and followed deit for six months we massacred INS, IR and FBG ,before and after treatm. Result: highly significant decrease(p<0.01) in INS level in group (A,B), AND significant decrease(p<0.05) in IR in all group (A,B,C),while non significant change hn FBG. Conclusions used cholin & inositol plus metformin could be as a first- line treatment in patients with PCOS.

Keywords: hormonal disturbances, including hyperandrogenemia, insulin resistance (IR), and hyperinsulinemia.


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