Abstract

SPECTROPHOTOMETRIC DETERMINATION OF METHYLDOPA IN PHARMACEUTICALS DOSAGE FORMS BY BROMINATION METHOD

*Dr. Mallapu. E. Rani

*Head of the Dept of Chemistry, Rayalseema University, Kurnool, Andhra Pradesh, India.

ABSTRACT

A Spectrophotometric method is described for assay of Methyldopa in tablets. In this method, the Methyldopa was brominated with bromate – bromide mixture under strong acidic condition. After bromination, the excess brominating mixture is treated with methylene blue; the stable grass green coloured complex was formed. The absorbance of the grass green colour was measured at 670 mm against the blank solution. Results of analysis were validated statistically and by recovery studies. The proposed method is successfully applied to the determination of Methyldopa in tablets.

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