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Abstract

TARGETED AND CONTROLLED DELIVERY OF ALGINATE-BASED ENCAPSULATION OF DOXORUBICIN IN EGFR –RELATED BREAST CARCINOMA

Myla Santiago* and Mark Kevin Devanadera

ABSTRACT

Doxorubicin hydrochloride (DOX) is used in treating ovarian, lung, and breast cancers. Its use in cancer chemotherapy is limited due to short plasma circulation, long elimination half-life, and non-specific cytotoxicity that may affect the normal cells. Thus, we have designed a drug delivery system, using a naturally occurring anionic polymer that is used for drug delivery due to its inert nature, high degree of biocompatibility, low toxicity, inexpensive and mild gelation with divalent cations such as calcium in forming particles. In this research, calcium alginate was used to encapsulate doxorubicin and assessed its compatibility with calcium alginate as drug delivery system. pH compatibility of alginate particle formation were assessed relative to the affinity of DOX. Alginate efficiency to encapsulate DOX was also tested and characterized through morphological analysis of the particles with the use of phase contrast microscope and scanning electron microscope (SEM). Fourier transform infrared spectrophotometer (FTIR) was used to confirm if the DOX was able to encapsulate within the alginate particles. Results showed that alginate encapsulation was compatible with DOX at neutral pH and encapsulation efficiency was achieved at 99.30%±0.0045 for 10ppm of DOX and 95.16%±0.011 for the 1.25ppm of DOX. An observable DOX-alginate particles with size average of 100-300μm using phase contrast microscope (40-60X magnification) and scanning electron microscope (200-300X magnification). DOX release in phosphate buffered saline (pH 7.2) confirmed that the DOX was successfully encapsulated based in FTIR data with comparable differences in the functional groups of DOX, alginate, and DOX released from the particles.

Keywords: Calcium Alginate, Doxorubicin, Encapsulation, Ionotropic Gelation.


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