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Nasreen Chaudhary*, Rachana D Sarawade, Neelam Kanade and Pranali Paradkar


Neuropathic pain is mainly generated by disorders of the peripheral and central nervous system, which can be particularly severe and disabling. Prevalence estimates indicate that majority of the population in the developed world suffer from Neuropathic pain. Clinically, Neuropathic pain is characterized by spontaneous ongoing or shooting pain responses after noxious or non-noxious stimuli and the type of pain evoke is hyperalgesia and allodynia. Identification of various pathophysiological mechanisms, such as central and peripheral sensitization and clinical assessment of signs and symptoms can help to determine the better targets in management of specific neuropathic pain disorders. Neuropathic pain responds poorly to conventional analgesics, thus management of neuropathic pain conditions based on the best scientific evidence in the literature should be followed. Treatment must be individualized for each patient which should be mechanism based, efficacy of drug, side-effect profile and drug accessibility, including cost. The aim of this review is to give a brief knowledge on target based pathophysiological mechanisms and treatment strategies of Neuropathic pain.

Keywords: Neuropathic Pain, Hyperalgesia, Allodynia, Central and Peripheral sensitization.

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