PHARMACOLOGICAL REVIEW ON NEUROPATHIC PAIN MANAGEMENT
Nasreen Chaudhary*, Rachana D Sarawade, Neelam Kanade and Pranali Paradkar
ABSTRACT
Neuropathic pain is mainly generated by disorders of the peripheral
and central nervous system, which can be particularly severe and
disabling. Prevalence estimates indicate that majority of the population
in the developed world suffer from Neuropathic pain. Clinically,
Neuropathic pain is characterized by spontaneous ongoing or shooting
pain responses after noxious or non-noxious stimuli and the type of
pain evoke is hyperalgesia and allodynia. Identification of various
pathophysiological mechanisms, such as central and peripheral
sensitization and clinical assessment of signs and symptoms can help
to determine the better targets in management of specific neuropathic
pain disorders. Neuropathic pain responds poorly to conventional
analgesics, thus management of neuropathic pain conditions based on the best scientific
evidence in the literature should be followed. Treatment must be individualized for each
patient which should be mechanism based, efficacy of drug, side-effect profile and drug
accessibility, including cost. The aim of this review is to give a brief knowledge on target
based pathophysiological mechanisms and treatment strategies of Neuropathic pain.
Keywords: Neuropathic Pain, Hyperalgesia, Allodynia, Central and Peripheral sensitization.
[Full Text Article]