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Abstract

IN VITRO AND IN VIVO ANTI HEPATOTOXIC EVALUATION OF ALPINIA GALANGA ON D- GALACTOSAMINE INDUCED TOXICITY

Srividya Ammayappan Rajam*, Sameer Kumar Varma, Vishnuvarthan Vaithiyalingam Jagannathan

ABSTRACT

Alpinia galangal is a rhizome belongs to the family Zingeberaceae. Qualitative phytochemical analysis of plant extracts showed the presence of majority of the compound including terpenoids, flavonoids, alkaloids, tannins, saponins and glycosides. The hydro alcoholic hot extract has shown high total phenol content 14.50 ± 0.210 mg/g and hydro alcoholic cold shown 12.59 ± 0.295 mg/g. Alpinia galangal hydro alcoholic extract prepared by hot maceration showed potent antioxidant activity with IC value 7.7 ± 0.121 μg/ml. The antihepatotoxicity produced by the extract at concentration of 200 and 400 μg/ml was effective against the D- Galactosamine induced hepatotoxicity, whereas at the concentration of 600 and 800 μg/ml it was found to be cytotoxic for both the hydro alcoholic extracts prepared by cold and hot maceration process. A significant increase in the levels of ASAT, ALAT, ALP, total Bilirubin, direct Bilirubin (P<0.001) and a significant reduction in the levels of TGL, total proteins and albumin (P< 0.001) was observed in hepatocytes exposed to D- Galactosamine when compared to normal hepatocytes. These cells when treated alone with different extract of Alpinia Galanga showed a significant restoration of the altered biochemical parameters towards the normal (P< 0.001) when compared to D- Galactosamine treated group) and were dose dependent. A similar result was obtained with the silymarin. The antihepatotoxic effect of extracts of Alpinia galangal was found to be 200 – 400 μg/ml concentration.

Keywords: Alpinia galangal, anti hepatoxicity, antioxidant, cytotoxic.


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