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Abstract

ANTIDIABETIC POTENTIAL OF WHOLE PLANT OF PHYLLANTHUS NIRURI

Savita Pal, Arvind Mishra, Arun Kumar Rawat, Rakesh Maurya and Arvind Kumar Srivastava*

ABSTRACT

The present study focused to study the antidiabetic activity of the
whole plant of Phyllanthus niruri in validated animal models of
diabetes. The crude powder, 95% ethanolic, 50% ethanolic and
aqueous extracts of whole plant of Phyllanthus niruri leaves were
orally administered to normoglycemic and streptozotocin (STZ)-
induced diabetic rats. 95% ethanolic extract showed marked
improvement on oral glucose tolerance post sucrose load in normal rats
and significantly lowered the fasting blood glucose level of STZinduced
diabetic rats. Administration of 95% ethanolic extract showed
marked antidyslipidemic effect on high fructose high fat diet fed
Syrian golden hamsters. Further, the isolated fractions, the aqueous, nbutanol,
chloroform, and hexane soluble fractions of 95% ethanolic
extract of whole plants were investigated for their antihyperglycemic effect on STZ-induced
diabetic rats. Of these, hexane fraction showed significant antihyperglycemic activity on
STZ-induced diabetic rats at a single dose (100 mg/kg body weight). In a multiple dose study,
hexane fraction when given to STZ-induced diabetic rats continuously for 30 days, the level
of percent glycated hemoglobin (%HbA1c), blood glucose, hepatic and renal function
markers were found towards normalization and improvement in serum insulin level and oral
glucose tolerance test (OGTT) were also observed. The marked improvements in OGTT and
serum insulin levels were also seen in neonatally STZ-induced diabetic rats. The hexane fraction effectively increased the glucose uptake by L-6 myotubes and inhibited the activityof alpha (α)-glucosidase and aldose reductase enzymes. Therefore, the findings concludes hexane fraction of 95% ethanolic extract of whole plant of P. niruri with antidiabetic potential.

Keywords: Antidiabetic activity, Antihyperglycemic activity, Glucose uptake, Neonatal-STZ induced diabetic rats, Phyllanthus niruri whole plant, L-6 myotubes.


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