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Abstract

FORMULATION AND EVALUATION OF MOUTH DISSOLVING LANSOPRAZOLE TABLET

Uma Shankar Mishra*, Prof.Dr.S.K.Prajapati, Dr.P.Bhardwa

ABSTRACT

In the present investigation of research is oriented through increasing safety and efficacy of existing drug molecule through novel concept of oral drug delivery Lansoprazole is a synthetic steroid that has an Anti-Ulcer Agents, Enzyme Inhibitors ,Proton-pump Inhibitors effect. It is used to decrease in Anti-Ulcer Agents various different diseases and conditions. Lansoprazole works by acting within cells to prevent the release of certain chemicals that are important in the immune system. These chemicals are normally involved in producing immune and allergic responses; resulting in Anti-Ulcer Agents .By decreasing the release of these chemicals in a particular area, Anti-Ulcer Agents is reduced. This can help control a wide number of disease states characterized by excessive. Anti-Ulcer Agents. These include severe allergic reactions, Anti-Ulcer Agents of the stomach. Mouth dissolving tablets of Lansoprazole were prepared by Superdisintegrant addition method using Kyron T 314, PolyKoVidone XL, SSG, and Croscarmellose sodium as superdisintegrants at 5-10% w/w, showed minimum time to disintegrate the tablet.(20) The prepared 12 batches were evaluated for organoleptic properties, hardness, friability, weight variation, in vitro dispersion time, wetting time, in vitro drug release studies, in vivo and stability studies. The drug-excipients interaction was checked and found negative through IR. Finally it was concluded that Mouth dissolving tablets oflansoprazole can be successfully formulated by Superdisintegrant addition methods with improved patient compliance.

Keywords: Mouth dissolving tablets, Lansoprazol, Kyron T-314, and PolyKoVidone XL, Direct compression method.


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