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Pradeep Paudel*, Deepa Dhungana, Sukriti Ghimire and Bhumika Khatri


Resistant to therapeutic regimen of enteric fever is a global problem. Such a resistance has led to treatment failure of Enteric fever. Therefore, it is necessary to study the sensitivity and resistance pattern of the drugs used in Enteric fever. This study was conducted to determine the susceptibility pattern of Salmonella Typhi causing enteric fever towards different antimicrobials. In this study, out of 145 isolates, 108 were confirmed to be S. Typhi by different Gram’s staining and along with different biochemical tests. In this study, S. Typhi was tested for 5 antibiotics i.e. Ciprofloxacin, Ofloxacin, Levofloxacin, Ceftriaxone and Chloramphenicol. This study showed the highest sensitivity for Chloramphenicol (97.22%), Ceftriaxone (79.62%), levofloxacin (68.51%), Ofloxacin (50.92%) and Ciprofloxacin (2.77%). Ciprofloxacin was the most resistant drug against S. Typhi. A total of 19 isolates were found to be multi drug resistant isolates (MDR). The MIC value for ciprofloxacin ranged from 55μg/ml to 100μg/ml. Among the 10 isolates, all the isolates were resistant to Ciprofloxacin (MIC ≤1μg/ml). The MIC value ranged from 12.5μg/ml to 100μg/ml for ofloxacin. All the 10 isolates were resistant to Ofloxacin as CLSI standard (≤2μg/ml). MIC for Ceftriaxone was found to be 25μg/ml. Three out of ten isolates were found to be sensitive, 5 were intermediate and 2 isolates showed resistant MIC value(<8μg/ml sensitive). Resistance to most antibiotics is a major problem worldwide and is becoming a challenge to treat the infections. Hence, antibiotic susceptibility should be done periodically to provide the rational treatment of enteric fever.

Keywords: Sensitivity, Fluroquinolones, Ceftriaxone, Chloramphenicol, MIC.

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