Abstract

ASSESSMENT OF OXIDATIVE STRESS AND ANTIOXIDANT STATUS IN PATIENTS OF ACUTE RENAL FAILURE WITH SEPSIS

V. Rattan, C.P. Hans, S.D Cruz, Rajiv Pathak, Pinkesh Rao4 and Snehal Mehta*

ABSTRACT

Role of reactive oxygen species in the pathogenesis of a variety of human diseases including toxic or ischemic acute renal failure (ARF) and sepsis has been reported. Therefore, in the present study, to assess the oxidative stress and antioxidant status, the plasma peroxidation products, ascorbic acid, vitamin E, catalase, total thiol groups and the erythrocyte reduced glutathione levels were measured in 65 patients of ARF with sepsis and 30 age and sex-matched normal healthy volunteers. A significant increase in plasma MDA (lipid peroxidation products; p<0.001) and catalase activity (p<0.01) with a concomitant significant decrease in plasma ascorbic acid (p<0.001), vitamin E (p<0.01), total thiols (p<0.001) and erythrocyte reduced glutathione (p<0.001) was observed in ARF patients with sepsis compared to normal healthy persons. These observations indicate that imbalance between pro-oxidant and antioxidant levels may play an important role in the pathophysiology of ARF.

Keywords: Oxidative stress, Antioxidants, Acute Renal Failure, Sepsis