ASSESSMENT OF OXIDATIVE STRESS AND ANTIOXIDANT STATUS IN PATIENTS OF ACUTE RENAL FAILURE WITH SEPSIS
V. Rattan, C.P. Hans, S.D Cruz, Rajiv Pathak, Pinkesh Rao4 and Snehal Mehta*
ABSTRACT
Role of reactive oxygen species in the pathogenesis of a variety of
human diseases including toxic or ischemic acute renal failure (ARF)
and sepsis has been reported. Therefore, in the present study, to assess
the oxidative stress and antioxidant status, the plasma peroxidation
products, ascorbic acid, vitamin E, catalase, total thiol groups and the
erythrocyte reduced glutathione levels were measured in 65 patients of
ARF with sepsis and 30 age and sex-matched normal healthy
volunteers. A significant increase in plasma MDA (lipid peroxidation
products; p<0.001) and catalase activity (p<0.01) with a concomitant
significant decrease in plasma ascorbic acid (p<0.001), vitamin E
(p<0.01), total thiols (p<0.001) and erythrocyte reduced glutathione
(p<0.001) was observed in ARF patients with sepsis compared to normal healthy persons.
These observations indicate that imbalance between pro-oxidant and antioxidant levels may
play an important role in the pathophysiology of ARF.
Keywords: Oxidative stress, Antioxidants, Acute Renal Failure, Sepsis
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