WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

DRUG SAFETY EVALUATION OF ANTI-PSYCHOTICS IN SCHIZOPHRENIA: A PROSPECTIVE OBSERVATIONAL STUDY IN A TERTIARY CARE HOSPITAL

K. Srilakshmi Silpa, Saripudi Aparna*, Pamidi Pradeep and Dr.N.Murali Krishna

ABSTRACT

Background: Schizophrenia is a severe form of mental illness, with a variety of positive, negative, cognitive and mood symptoms, antipsychotic medications can have dramatic impact in patient life leads to many side effects. The purpose of this study was to observe Side Effects (weight gain, Blood Pressure, Sedation and Extra Pyramidal Side Effects) of Anti-Psychotics (Chlorpromazine, Haloperidol Vs Olanzapine, Risperidone). Method: A prospective observational study has been carried out in Government General Hospital, Guntur for a study period of 6 months i.e., March-August 2014. Number of patient enrolled with antipsychotics were Haloperidol (n=15), Chlorpromazine (n=15), Risperidone (n=35) and Olanzapine (n=25), a total of (n=90) patients. Results: Olanzapine resulted in 4kg and risperidone of 2kg increased weight were seen. Extra pyramidal side effects observed with haloperidol and risperidone were dystonia, tremors and rabbit syndrome. A sedation profile observed with chlorpromazine (80%), olanzapine (36%) and their incidence of sedation was compared, which shows that chlorpromazine caused more sedation than olanzapine in case of schizophrenic patients. Conclusion: Prominent Side effects were observed with haloperidol, and risperidone compared to olanzapine, and chlorpromazine. Weight gain was much observed with olanzapine than risperidone. Sedation was more with chlorpromazine than olanzapine and extra pyramidal side effects were predominantly found with haloperidol, whereas the metabolic side effects predominated the atypical antipsychotics.

Keywords: schizophrenia, anti-psychotics, weight gain, sedation, extra pyramidal side effects.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More