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Abstract

PEDIATRIC SEIZURES - A PROSPECTIVE STUDY ON DRUG UTILIZATION PATTERN AND ITS OUTCOME IN A TERITIARY CARE HOSPITAL

A.Ramya, M.Poornima Sravya*, M.Vinod Kumar, Dr. A. Thirupathi Reddy, Dr. Ch. Chaitanya Lakshmi

ABSTRACT

OBJECTIVES: The objective of this study is to evaluate the drug utilization pattern and to observe possible treatment outcomes. METHODS: A Non-experimental prospective observational study has been carried out in tertiary care hospital for a period of six months. A total number of 181 pediatric inpatients of age 1- 14 years with seizures were included and evaluated. The patient case history was collected based on data collection form designed for the study. RESULTS: In our study we observed that female patients are more prevalent. Prevalence of seizures is high among age group 1-5years and low among 11-14 years. Tonic-clonic (51.3%) type of seizures were commonly observed, followed by febrile seizures (19%). Phenytoin is the mostly prescribed drug followed by sodium valproate. Monotherapy is observed mostly. Outcome of the therapy is measured by seizure free period, among which seizure free observed are more 74.1%. The incidence of ADRs in the study group is less (6.6%) and phenytoin is the drug with more number of ADRs. Medication adherence is measured in known epileptic patients(n=67) using MMAS, medium adherence seems to be more (49%). CONCLUSION: This study strongly highlights that the, Clinical pharmacist has a pivot role in conducting drug utilization studies that helps in comparing the ongoing regimen with the standard treatment guidelines so as to promote the stupendousity of rational use of drugs and to minimize or control the incidence of ADRs.

Keywords: Drug utilization, seizure, anti-epileptics, Morisky’s scale.


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