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Abstract

DEVELOPMENT AND VALIDATION OF HPTLC (HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHY) METHOD FOR SIMULTANEOUS ESTIMATION OF LORNOXICAM AND PARACETAMOL IN PHARMACEUTICAL DOSAGE FORM

Vyas Janki T.*, Dr. Zarna R. Dedania, Dr. S.M.Vijyendraswamy.

ABSTRACT

Novel analytical Chromatographic HPTLC method has been developed in presented research work for simultaneous estimation of Lornoxicam and Paracetamol in pharmaceutical dosage form. HPTLC separation was also achieved on precoated silica gel 60GF254 using Acetone:Choloroform:Formic acid (4:4:2) as a mobile phase. Quantification was achieved with UV detection at 254 nm. The Rf value of Lornoxicam was found to be 0.47+0.02 and Rf value of Paracetamol was found to be 0.28+0.01. Calibration curve were linear in the range of 64-320 ng/spot for Lornoxicam and 2600-13000 ng/spot for Paracetamol. The assay results were found to be 98.85-101.32% for Lornoxicam and 99.84-101.18% for Paracetamol. Validation of the proposed method was carried out for its accuracy and precision according to ICH guidelines. The methods were found to be rapid, simple, accurate and precise. Thus the present study gives excellent method for the determination of these two drugs in combined dosage formulation without their prior separation. They enable the simultaneous determination of Lornoxicam and Paracetamol in tablet dosage form.

Keywords: Lornoxicam, Paracetamol, HPTLC method, Validation.


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