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Abstract

VALIDATION, ESTIMATION AND RECOVERY STUDIES OF ETOPOSIDE IN BULK AND INJECTABLE DOSAGE FORMS USING RP-HPLC AND UV-VISIBLE SPECTROSCOPY

Deepak Tripathi*, Mr. Ravinder Mohanty, Hemant Bhardwaj, Jatin Jaiswal

ABSTRACT

A simple, sensitive precise and specified reverse phase high performance liquid chromatographic method was developed and validated for determination of Etoposide in bulk and injectable dosages form. It is found that the excipient in the formulation does not interfere in the quantification of active drug by proposed method. The HPLC separation was carried out by reverse phase chromatography on NH2- (250mm×4.6mm) 5 μm with mobile phase composed of 0.030 M Sodium acetate Buffer pH 4.0: Acetonitrile (70:30) in isocratic mode at flow rate of 1.2 ml/min. The detection was monitored at 254 nm at ambient temperature. The calibration curve of Etoposide is linear from 100 ppm to 300 ppm. The accuracy (recovery 98-102.4%) and reproducibility is satisfactory.

Keywords: Etoposide, RP-HPLC Method, Acetonitrile, Validation.


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