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Abstract

ENHANCEMENT OF SOLUBILITY OF ACECLOFENAC BY SOLID DISPERSION USING BIOPOLYMER OBTAINED FROM PRUNUS ARMENIACA

Kamal Kishor Joshi*, D. K. Sharma and Arun Kumar Singh

ABSTRACT

In the drug delivery system solubility plays a crucial factor for drug absorption and its bioavailability. Solubility is the main limiting factor for BCS class II category of drug. The objective of present study was to isolate and characterize biopolymer from the fruits of Prunus armeniaca belonging to rosaceae family. In the recent years the research in the biopolymer isolation and their use as pharmaceutical excipient become a core area for formulation scientist to develop safe and effective drug delivery system. The biomaterial was isolated by non solvent addition method and characterized their physiochemical, phytochemical and micromeritic properties. In the present study the attempt was made to enhance the solubility of aceclofenac by solid dispersion technique, using biomaterial as a hydrophilic carrier. Aceclofenac is a nonsteroidal anti-inflammatory drug acting by inhibition of the synthesis of prostaglandins by inhibiting the activity of the enzyme, cyclooxygenase-2(COX-2).Five different ratios of biopolymer and acelofenac(1:1, 1:1.5, 1:2, 1:2.5 and 1:3) were used and solid dispersion was prepared by fusion method. The aqueous solubility of each formulation was determined and compared with the solubility of pure aceclofenac. Result from study shows that by using biopolymer as carrier, the tremendous increase in the solubility was found as compared to the standard. So the biopolymer serves as a better alternative exicepient for the development of dosage form because of safe, non toxic, biocompatible and biodegradable and easily acceptable by regulatory bodies.

Keywords: Biopolymer, Aqueous solubility Solid dispersion technique, Prunus armeniaca.


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