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Abstract

URINARY TRACT INFECTIONS CAUSED BY PSEUDOMONAS, KLEBSIELLA AND PROTEUS SPECIES: A 2005-2009 SURVEY OF TRENDS IN THEIR INFECTIVITIES AND SUSCEPTIBILITIES TO SELECTED FLUOROQUINOLONES IN A TERTIARY HOSPITAL IN NIGERIA

John David OHIEKU* and Rilwanu Aminu MAGAJI

Department of Clinical Pharmacy and Pharmacy Administration, Faculty of Pharmacy, University of Maiduguri, P.M.B. 1069, Maiduguri, Borno State, Nigeria.

ABSTRACT

Fluoroquinolones (FQs) have become agents of therapeutic interest since it is one of the few anti-infective treatment options in many regions. This study examines trends in the activities of the FQs to some Urinary Tract Infection (UTI) pathogens with multi-drug resistances that are often difficult to treat; so as to identify the changing pattern in pathogenís infectivity or susceptibilities to FQs, investigate multi-FQs resistance patterns and the inter-activity relations of the FQs. Of the 1590 UTI pathogens isolated between 2005 and 2009, Klebsiella spp, Proteus spp and Pseudomonas spp accounted for 10%, 4.7% and 3.0% respectively; making them to rank third, fourth and fifth most infectious UTI pathogens in the region. The susceptibilities changes (decrease) of UTI Klebsiella spp with ciprofloxacin, ofloxacin, pefloxacin, and nalidixic acid were 7.6%, 4.3%, 11.5% and 19.7% respectively. The activities of ofloxacin was significantly higher (P<0.05) than ciprofloxacin in pefloxacin-resistant Klebsiella. A 37.5% decrease in ciprofloxacin activities against Proteus spp were recorded but pefloxacin activities appreciated by 11.5% during the 5 year periods. Ciprofloxacin and ofloxacin recorded uniform activities of 58.9% each against nalidixic acid-resistant Proteus UTI isolates. The susceptibility of Pseudomonas increased from 20% in 2005 to 75% in 2009. Resistance rates to three and four quinolones were respectively 18.9% and 11.3% for Klebsiella; 31.7% and 20.8% for Pseudomonas but 10.8% each for Proteus spp. Resistances to Pseudomonas, Proteus and Klesiella spp have exceeded 20% and newer agents may be required to treat some cases because multi-FQs resistant pathogenic isolates are on the increase.

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