FORMULATION AND EVALUATION OF TRAMADOL HCL SUSTAINED RELEASE MATRIX TABLETS
Akunuri. Premalatha*, Dr. V. Raj Kumar, Rakam. Gopi Krishna and Kuchi. Manjeera
ABSTRACT
The present work was an aim to prepare a suitable extended release
tablet of Tramadol HCL, which could reduce the dosing frequency and
improve patient compliance. Extended release tablets were prepared
using HPMC10000cps & Acacia as retardant polymers. Various
evaluation parameters were evaluated and the results were found to be
satisfactory. On comparing equation of line and regression coefficient
(R2) innovator, the formulation F4 shows similarity of results with
innovator. Hence F4 was considered as formulation extending 98.96%
of drug was released at the end of 10hrs. The stability studies were
carried out for a period of 3 monthsas per ICH guidelines and
were in acceptable limits.
Keywords: Tramadol Hydrochloride, Hydroxypropyl methylcellulose, Matrix tablets.
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