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Abstract

FORMULATION AND EVALUATION OF TRAMADOL HCL SUSTAINED RELEASE MATRIX TABLETS

Akunuri. Premalatha*, Dr. V. Raj Kumar, Rakam. Gopi Krishna and Kuchi. Manjeera

ABSTRACT

The present work was an aim to prepare a suitable extended release tablet of Tramadol HCL, which could reduce the dosing frequency and improve patient compliance. Extended release tablets were prepared using HPMC10000cps & Acacia as retardant polymers. Various evaluation parameters were evaluated and the results were found to be satisfactory. On comparing equation of line and regression coefficient (R2) innovator, the formulation F4 shows similarity of results with innovator. Hence F4 was considered as formulation extending 98.96% of drug was released at the end of 10hrs. The stability studies were carried out for a period of 3 monthsas per ICH guidelines and were in acceptable limits.

Keywords: Tramadol Hydrochloride, Hydroxypropyl methylcellulose, Matrix tablets.


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