STUDY OF NITROFURANTOIN SUSCEPTIBILITY AMONG UROPATHOGENIC BACTERIAL ISOLATES AT A TERTIARY CARE HOSPITAL, UDAIPUR, RAJASTHAN.
Ritu Bhatnagar*, Payal Soni, Sanjeev Kumar, S.K. Mehra, Aruna Solanki and Jyoti Tomar
ABSTRACT
Introduction: Urinary tract infections (UTIs) are some of the most
common infections experienced by humans.[1] Common bacteria
associated with community acquired infectons are E.coli, Coagulase
negative Staphylococci, Enterococcus fecalis, Staphylococcus aureus
etc.[2] As resistance to Fluroquinolones, Cephalosporins and Cotrimoxazole
has become more common in uropathogenes,
Nitrofurantoin has become an important alternative oral agent for
treatment of uncomplicated UTI.[12] Aim: to find out the sensitivity
pattern of the urinary isolates against different commonly used
antimicrobials in UTI with special reference to Nitrofurantoin.
Material and Methods: The study was performed from July 2014 to
December 2014 at tertiary care hospital, Udaipur, Rajastahn, India. Urine sample
from Clinically suspected (OPD and IPD) cases were collected.
Processing and identification was done as per standard guidelines. Antimicrobial sensitivity
testing was performed by Kirby- Bauer disc diffusion method. Result and Discussion: Total
498 test samples were analysed. Out of that, in 251 cases bacterial pathogens were isolated. The most common organisms isolated were Escherichia coli (58.17%) followed by Klebsiella sp. (13.94%), Enterococcus sp. (8.37%), Pseudomonas sp. (6.37%), and Coagulase negative Staphylococcus sp. (6.38%). Only 29 (11.5%) were resistant to Nitrofurantoin among oral antibiotics. Conclusion: Nitrofurantoin is a good choice for the treatment of outpatients.
Keywords: Nitrofurantoin, Urinary tract infections, Antimicrobial resistance pattern, Uropathogenic bacteria
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