Abstract

STUDY OF NITROFURANTOIN SUSCEPTIBILITY AMONG UROPATHOGENIC BACTERIAL ISOLATES AT A TERTIARY CARE HOSPITAL, UDAIPUR, RAJASTHAN.

Ritu Bhatnagar*, Payal Soni, Sanjeev Kumar, S.K. Mehra, Aruna Solanki and Jyoti Tomar

ABSTRACT

Introduction: Urinary tract infections (UTIs) are some of the most common infections experienced by humans.[1] Common bacteria associated with community acquired infectons are E.coli, Coagulase negative Staphylococci, Enterococcus fecalis, Staphylococcus aureus etc.[2] As resistance to Fluroquinolones, Cephalosporins and Cotrimoxazole has become more common in uropathogenes, Nitrofurantoin has become an important alternative oral agent for treatment of uncomplicated UTI.[12] Aim: to find out the sensitivity pattern of the urinary isolates against different commonly used antimicrobials in UTI with special reference to Nitrofurantoin. Material and Methods: The study was performed from July 2014 to December 2014 at tertiary care hospital, Udaipur, Rajastahn, India. Urine sample from Clinically suspected (OPD and IPD) cases were collected. Processing and identification was done as per standard guidelines. Antimicrobial sensitivity testing was performed by Kirby- Bauer disc diffusion method. Result and Discussion: Total 498 test samples were analysed. Out of that, in 251 cases bacterial pathogens were isolated. The most common organisms isolated were Escherichia coli (58.17%) followed by Klebsiella sp. (13.94%), Enterococcus sp. (8.37%), Pseudomonas sp. (6.37%), and Coagulase negative Staphylococcus sp. (6.38%). Only 29 (11.5%) were resistant to Nitrofurantoin among oral antibiotics. Conclusion: Nitrofurantoin is a good choice for the treatment of outpatients.

Keywords: Nitrofurantoin, Urinary tract infections, Antimicrobial resistance pattern, Uropathogenic bacteria