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Abstract

POST-MARKET DISSOLUTION PROFILE STUDY AND COST COMPARISION OF CEFADROXIL BRANDS AVAILABLE IN KARACHI (PAKISTAN).

Najia Rahim*, S.. Baqir S. Naqvi, Sana Ghayas, Rehana Bibi

ABSTRACT

The present work was undertaken to evaluate the performance of locally available cefadroxil brands. Another objective was the cost comparison among generic brands and reference brand. Assay and dissolution profile was studied using USP 31. Dissolution profiles were investigated in four solutions as recommended by FDA (0.1 N HCl, acetate buffer (pH = 4.5), phosphate buffer (pH = 6.8) and distilled water). DDSolver® excel based Add in program was used for dissolution profile comparison. F2 results revealed a mixed response, when drug release from cefadroxil marketed brands in four media was compared with that of reference brand. F2 results concluded that brand B and D were similar in drug release to that of reference formulation. Model dependent approach revealed that drug release was best fit in First order and Weibull model. Price comparison discovered that brand B, D and E have price differential in the range of 41.85-52.07%. Brand C has the lowest price differential of 23.32%. It was concluded that the pharmaceutical quality of local and multinational brands was analogous except few cases.

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