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Abstract

PHARMACOLOGICAL EVALUATION OF Passiflora incarnata ON VINCRISTINE INDUCED NEUROPATHY IN RATS

*Vijayalakshmi Chinniah, Venkata Rathina Kumar Thiagarajan, M. Selvakumar

ABSTRACT

The present study was designed to explore the anti-nociceptive effects
of hydroethanolic extract of Passiflora incarnata in vincristine induced
painful neuropathy in rats. The intraperitoneal administration of
vincristine 50 g/kg; for 10 consecutive days has been employed for
the induction of neuropathy. Hydroethanolic extract of Passiflora
incarnata (HEEPI)(100mg/kg, 200mg/kg; p.o) and pregabalin
(standard; 10mg/kg; p.o) has to be administered for 14 consecutive
days two hour before vincristine injection. Behavioural tests such as
paw heat hyperalgesic test, cold chemical allodynic test and tail heat
hyperalgesic test were assessed starting from day 0 and subsequently
on day 1, 3, 6, 9, 12, 15, 18 and 21st day. Further, the biochemical
changes i.e., thiobarbituric acid reactive substances (TBARS), reduced
glutathione (GSH)and total calcium levels has to be estimated in sciatic nerve tissue, on 21st
day after sacrificing the animal and histopathological changes has to be observed in sciatic
nerve tissue. Administration of vincristine resulted in significant changes in behavioural and
biochemical parameters. Pretreatment of HEEPI ameliorated vincristine induced behavioral,
biochemical and histopathological changes in a dose dependent manner, which is similar to
that of pregabalin pretreated group. The results suggests that, the neuroprotective effect of
Passiflora incarnata may be due to its potential of anti-oxidative, calcium channel
modulating and neuroprotective action

Keywords: Vincristine, Biochemical changes, Passiflora incarnata, Calcium channel modulating effect, Oxidative stress.


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