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Abstract

SPECTROPHOTOMETRIC DETERMINATION OF AN ANTIMALARIAL DRUG PRIMAQUINE IN BULK AND PHARMACEUTICAL FORMULATIONS

Manjusha D.Karad and Dr.V.D.Barhate*

ABSTRACT

A simple, sensitive and accurate spectrophotometric method have been developed for the determination of primaquine in pure and dosage forms. Method is based on oxidation of the drug with 1, 10 phenanthroline producing orange colored chromogen which is measured at 520 nm. Beer’s law is obeyed in the concentration range of 10-200 μg/mL for the developed method. The molar absorptivity and sandell sensitivity are found to be 22914 L mol-1cm-1 and 0.011μg/cm2 respectively. The regression equation for primaquine was found to be y = 0.0041X + 0.0223and the correlation coefficient for the regression line was 0.999. Different experimental parameters affecting the color development and stability of colored product are carefully studied and optimized. The developed method could be successfully applied to pharmaceutical formulations. The results obtained are in good agreement with those obtained using standard method.

Keywords: primaquine Spectrophotometry, dosage forms, 1, 10-phenanthroline (OPHEN).


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