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Abstract

INFLUENCE OF DIETARY ASCORBIC ACID INTAKE ON THE INCIDENCE OF MICRONUCLEI AND SISTER CHROMATID EXCHANGES IN WOMEN BEEDI WORKERS EXPOSED TO TOBACCO DUST

P. Minny Jael and K. Rudrama Devi*

ABSTRACT

India is the third largest producer of leaf tobacco in the world; it is also a very large consumer of tobacco products. More than five million individuals are involved in the production of beedies in India. Typically, an individual beedi may contain roughly 0.2 to 0.5 grams of pulverized sun- cured locally grown tobacco in a tendu or temburi leaf obtained from native plants, Diospyros melanoxylon or Diospyros ebenum respectively. The sun dried tobacco filler is hand rolled using a leaf cut into a cylindrical shape and secured with a thread. These beedi rollers work in small factories or at household- base enterprises in an environment laden with tobacco dust. Individuals working 6 to 10 hr/day inhale, swallow and explore their skin and mucous surface to significant amounts of particulate tobacco. A population monitoring study was conducted in human lymphocytes by analysis of micronuclei and sister chromatid exchanges to investigate whether occupational exposure to tobacco dust is genotoxic towomen bidi rollers. There was significant increase in the frequency of micronucleiand Sister Chromatid Exchanges in human lymphocytes. In addition, a study on the antimutagenic effect of Vitamin C administered orally to tobacco exposed workers was investigated by measuring the frequency micronuclei and sister chromatid exchanges had a three month daily intake of Vitamin C. The results clearly showed a significant reduction on chromosomal aberrations and sister chromatid exchanges frequency evaluated after vitamin-C treatment. This results of present study indicate the protective nature of AA supplementation in tobacco xposed workers and beneficial to compensate hazards due to tobacco exposure.

Keywords: Ascorbic acid, Sister chromatid exchanges, human lymphocytes, lead battery industry workers.


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