WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

COMPARATIVE STUDY OF SYNTHESIS OF 2, 4, 5-TRIARYL SUBSTITUTED IMIDAZOLES UNDER SOLVENT FREE CONDITIONS USING DIFFERENT LEWIS ACIDS AS CATALYSTS

Satish Patil*, Jayesh Patil and Sadanand Dharap

ABSTRACT

A range of 2, 4, 5-triaryl substituted imidazoles have been synthesized in very good yields under solvent-free conditions by grinding 1, 2- diketone, aromatic aldehydes and ammonium acetate in the presence of I2, NaH2PO4 and SnCl2.2H20 as catalysts. Optimization of reaction conditions were carried out using different amount of catalysts. 10 mol% catalysts were found to be sufficient catalyze the reaction with high yield. Rate of synthesis of imidazoles and yield of the products were found to be directly proportional to the acidity of Lewis acid catalysts. The short reaction time, green reaction, and simple operation make this protocol practical and economically attractive. Effectiveness of catalysts was found to be of the order of SnCl2.2H2O>NaH2PO4>I2.

Keywords: Triaryl imidazoles, Lewis acids, catalysts, solvent free.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More