WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

PREPARATION AND CHARACTERIZATION OF TERNARY SOLID DISPERSION OF FLUNARIZINE DIHYDROCHLORIDE

*Hitesh V. Chavda, Ruchi I. Patel, Chhagan N. Patel

ABSTRACT

Introduction: The ternary solid dispersion was developed to improve the Solubility and dissolution of drug. Materials and Methods: Binary and ternary solid dispersions were prepared by fusion and solvent evaporation method. They were characterized by solubility study, in vitro dissolution and dissolution efficiency. The solid state properties of solid dispersions were characterized by different ial scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FTIR). Results: Optimized ternary solid dispersion containing ratio 1:2:2 of drug: PEG 6000: Pluronic F68 gave highest solubility with maximum dissolution. The FTIR, and DSC studies of solid dispersions were confirmed the formation of solid dispersion. Conclusion: The studies indicated that the solubility and dissolution of drug was improved in the presence of ternary agent (surfactant) as compared to binary solid disersion.

Keywords: Fusion method, PEG 6000, Pluronic F68, Flunarizine Dihydrochloride, ternary solid dispersion.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More