PREPARATION AND CHARACTERIZATION OF TERNARY SOLID DISPERSION OF FLUNARIZINE DIHYDROCHLORIDE
*Hitesh V. Chavda, Ruchi I. Patel, Chhagan N. Patel
ABSTRACT
Introduction: The ternary solid dispersion was developed to improve
the Solubility and dissolution of drug. Materials and Methods:
Binary and ternary solid dispersions were prepared by fusion and
solvent evaporation method. They were characterized by solubility
study, in vitro dissolution and dissolution efficiency. The solid state
properties of solid dispersions were characterized by different ial
scanning calorimetry (DSC) and Fourier transform infrared
spectroscopy (FTIR). Results: Optimized ternary solid dispersion
containing ratio 1:2:2 of drug: PEG 6000: Pluronic F68 gave highest
solubility with maximum dissolution. The FTIR, and DSC studies of
solid dispersions were confirmed the formation of solid dispersion.
Conclusion: The studies indicated that the solubility and dissolution of
drug was improved in the presence of ternary agent (surfactant) as
compared to binary solid disersion.
Keywords: Fusion method, PEG 6000, Pluronic F68, Flunarizine Dihydrochloride, ternary solid dispersion.
[Full Text Article]