Abstract

PREPARATION AND CHARACTERIZATION OF TERNARY SOLID DISPERSION OF FLUNARIZINE DIHYDROCHLORIDE

*Hitesh V. Chavda, Ruchi I. Patel, Chhagan N. Patel

ABSTRACT

Introduction: The ternary solid dispersion was developed to improve the Solubility and dissolution of drug. Materials and Methods: Binary and ternary solid dispersions were prepared by fusion and solvent evaporation method. They were characterized by solubility study, in vitro dissolution and dissolution efficiency. The solid state properties of solid dispersions were characterized by different ial scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FTIR). Results: Optimized ternary solid dispersion containing ratio 1:2:2 of drug: PEG 6000: Pluronic F68 gave highest solubility with maximum dissolution. The FTIR, and DSC studies of solid dispersions were confirmed the formation of solid dispersion. Conclusion: The studies indicated that the solubility and dissolution of drug was improved in the presence of ternary agent (surfactant) as compared to binary solid disersion.

Keywords: Fusion method, PEG 6000, Pluronic F68, Flunarizine Dihydrochloride, ternary solid dispersion.